In vitro immunomodulatory effects of microencapsulated umbilical cord Wharton jelly-derived mesenchymal stem cells in primary Sjögren’s syndrome

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In vitro immunomodulatory effects of microencapsulated umbilical cord Wharton jelly-derived mesenchymal stem cells in primary Sjögren's syndrome.

OBJECTIVE Human umbilical cord Wharton jelly-derived mesenchymal stem cells (hUCMS) are easy to retrieve in bulk. They may interact with immune cells by either cell contact or soluble factors. Little evidence is currently available on potential therapeutic application of hUCMS to systemic autoimmune disorders such as primary SS (pSS). We have recently developed an endotoxin-free alginate gel th...

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The effects of umbilical cord Wharton jelly derived mesenchymal stem cells injection on diabetic wound healing in male rats

Background: The number of patients suffering from diabetic ulcers has been increased in recent years and the current therapies have faced failure. This study aimed to investigate the effects of Wharton’s jelly stem cells (WJMSCs) on the diabetic wound in an animal mode. Methods: During this laboratory experimental study carried out in Skin and Stem Cells Research Center from March 2021 to Nove...

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In-vitro Differentiation of Human Umbilical Cord Wharton’s Jelly Mesenchymal Stem Cells to Insulin-Producing Cells

  Background & Objective: Diabetes is a major chronic metabolic disease in the world. Islet transplantation is a way to treat diabetes. Unfortunately, this method is restricted due to graft rejection and lack of donor islets. Mesenchymal Stem Cells (MSCS) have the ability to differentiate into Insulin-Producing Cells (IPCs). In this study, Human Umbilical Mesenchymal Stem Cells (HUMSCS) were in...

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immunomodulatory effects of human umbilical cord wharton's jelly-derived mesenchymal stem cells on differentiation, maturation and endocytosis of monocyte-derived dendritic cells.

the wharton’s jelly of the umbilical cord is believed to be a source of mesenchymal stem cells (mscs) which can be therapeutically applied in degenerative diseases. in this study, we investigated the immunomodulatory effect of umbilical cord derived- mesenchymal stem  cells (uc-mscs) and  bone  marrow-derived-mesenchymal stem  cells (bm-mscs) on differentiation, maturation, and endocytosis of m...

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Human Umbilical Cord Wharton Jelly-Derived Adult Mesenchymal Stem Cells, in Biohybrid Scaffolds, for Experimental Skin Regeneration

The ultimate goal for skin tissue engineering is to regenerate skin lesions to allow the full restoration of morphological and functional properties as what they were before injury. To this end, we have assembled a new prototype of a biomimetic human umbilical cord adult mesenchymal stem cell (hUCMS)/fibrin-based scaffold. We have fully characterized the proposed dermal equivalent (DE) in vitro...

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ژورنال

عنوان ژورنال: Rheumatology

سال: 2014

ISSN: 1462-0332,1462-0324

DOI: 10.1093/rheumatology/keu292